Treatment of interstitial lung disease in children.
Identifieur interne : 001F12 ( Main/Exploration ); précédent : 001F11; suivant : 001F13Treatment of interstitial lung disease in children.
Auteurs : R. Dinwiddie [Royaume-Uni]Source :
- Paediatric respiratory reviews [ 1526-0542 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- imagerie diagnostique : Pneumopathies interstitielles, Poumon.
- traitement médicamenteux : Pneumopathies interstitielles.
- étiologie : Pneumopathies interstitielles.
- Enfant, Humains, Pronostic, Tomodensitométrie.
English descriptors
- KwdEn :
- MESH :
- diagnostic imaging : Lung, Lung Diseases, Interstitial.
- drug therapy : Lung Diseases, Interstitial.
- etiology : Lung Diseases, Interstitial.
- Child, Humans, Prognosis, Tomography, X-Ray Computed.
Abstract
The treatment of interstitial lung disease in children depends on the nature of the underlying pathology. In approximately 50% of cases a specific aetiology can be found such as: chronic viral infection, an auto-immune process, sarcoidosis or alveolar proteinosis. In the remainder, the process is idiopathic and the pathological findings are based on the descriptive morphological features seen in the diagnostic lung biopsy. If a specific cause is found then targeted treatment with antivirals, steroids or other immunosuppressive agents is available. Alveolar proteinosis can be treated by bronchial lavage and GM-CSF. Idiopathic cases are treated primarily with intravenous pulsed methylprednisolone or oral prednisolone backed up hydroxychloroquine. Other immunosuppressive agents such as azathioprine, methotrexate or ciclosporin have been used successfully in individual patients. The prognosis is very variable and includes no response to any therapy, partial response with chronic long term morbidity, to virtually complete recovery. The overall mortality rate is 15%. There are no controlled therapeutic trials available because of the rarity of these conditions in childhood. Unlike in adult practice, no correlation has as yet been demonstrated between the initial pattern of chest x-ray change or the degree of pathological change on the lung biopsy and the clinical outcome. The recurrence rate within families is 1 in 8.
DOI: 10.1016/j.prrv.2004.01.004
PubMed: 15135120
Affiliations:
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Le document en format XML
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Dinwiddie</name><affiliation wicri:level="1"><nlm:affiliation>Respiratory Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK. r.dinwiddie@ich.ucl.ac.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH</wicri:regionArea><wicri:noRegion>London WC1N 3JH</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15135120</idno><idno type="pmid">15135120</idno><idno type="doi">10.1016/j.prrv.2004.01.004</idno><idno type="wicri:Area/PubMed/Corpus">000454</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000454</idno><idno type="wicri:Area/PubMed/Curation">000454</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000454</idno><idno type="wicri:Area/PubMed/Checkpoint">000429</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000429</idno><idno type="wicri:Area/Ncbi/Merge">000066</idno><idno type="wicri:Area/Ncbi/Curation">000066</idno><idno type="wicri:Area/Ncbi/Checkpoint">000066</idno><idno type="wicri:doubleKey">1526-0542:2004:Dinwiddie R:treatment:of:interstitial</idno><idno type="wicri:Area/Main/Merge">001F27</idno><idno type="wicri:Area/Main/Curation">001F12</idno><idno type="wicri:Area/Main/Exploration">001F12</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Treatment of interstitial lung disease in children.</title><author><name sortKey="Dinwiddie, R" sort="Dinwiddie, R" uniqKey="Dinwiddie R" first="R" last="Dinwiddie">R. Dinwiddie</name><affiliation wicri:level="1"><nlm:affiliation>Respiratory Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK. r.dinwiddie@ich.ucl.ac.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH</wicri:regionArea><wicri:noRegion>London WC1N 3JH</wicri:noRegion></affiliation></author></analytic><series><title level="j">Paediatric respiratory reviews</title><idno type="ISSN">1526-0542</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Humans</term><term>Lung (diagnostic imaging)</term><term>Lung Diseases, Interstitial (diagnostic imaging)</term><term>Lung Diseases, Interstitial (drug therapy)</term><term>Lung Diseases, Interstitial (etiology)</term><term>Prognosis</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Enfant</term><term>Humains</term><term>Pneumopathies interstitielles (imagerie diagnostique)</term><term>Pneumopathies interstitielles (traitement médicamenteux)</term><term>Pneumopathies interstitielles (étiologie)</term><term>Poumon (imagerie diagnostique)</term><term>Pronostic</term><term>Tomodensitométrie</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Lung</term><term>Lung Diseases, Interstitial</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lung Diseases, Interstitial</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lung Diseases, Interstitial</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Pneumopathies interstitielles</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Pneumopathies interstitielles</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Pneumopathies interstitielles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Humans</term><term>Prognosis</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Enfant</term><term>Humains</term><term>Pronostic</term><term>Tomodensitométrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The treatment of interstitial lung disease in children depends on the nature of the underlying pathology. In approximately 50% of cases a specific aetiology can be found such as: chronic viral infection, an auto-immune process, sarcoidosis or alveolar proteinosis. In the remainder, the process is idiopathic and the pathological findings are based on the descriptive morphological features seen in the diagnostic lung biopsy. If a specific cause is found then targeted treatment with antivirals, steroids or other immunosuppressive agents is available. Alveolar proteinosis can be treated by bronchial lavage and GM-CSF. Idiopathic cases are treated primarily with intravenous pulsed methylprednisolone or oral prednisolone backed up hydroxychloroquine. Other immunosuppressive agents such as azathioprine, methotrexate or ciclosporin have been used successfully in individual patients. The prognosis is very variable and includes no response to any therapy, partial response with chronic long term morbidity, to virtually complete recovery. The overall mortality rate is 15%. There are no controlled therapeutic trials available because of the rarity of these conditions in childhood. Unlike in adult practice, no correlation has as yet been demonstrated between the initial pattern of chest x-ray change or the degree of pathological change on the lung biopsy and the clinical outcome. The recurrence rate within families is 1 in 8.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Dinwiddie, R" sort="Dinwiddie, R" uniqKey="Dinwiddie R" first="R" last="Dinwiddie">R. Dinwiddie</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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